Modelling of impaired cerebral blood flow due to gaseous emboli
نویسندگان
چکیده
منابع مشابه
Modelling of impaired cerebral blood flow due to gaseous emboli.
Bubbles introduced to the arterial circulation during invasive medical procedures can have devastating consequences for brain function but their effects are currently difficult to quantify. Here we present a Monte Carlo simulation investigating the impact of gas bubbles on cerebral blood flow. For the first time, this model includes realistic adhesion forces, bubble deformation, fluid dynamical...
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Many bubbles that enter the brain circulation pass through the arterioles and capillary beds and do not obstruct blood flow. Nevertheless, such bubbles could still disrupt brain function. An open-brain model in five anesthetized rabbits used the minimum dose of air (25 microliters) necessary to cause embolism of the exposed vessels, and these bubbles passed through the vessels without any trapp...
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Better understanding of the determinants of cerebral blood flow (CBF) and the interpretation of clinical measurements can benefit from quantitative modelling of CBF regulatory mechanisms and their interaction with other haemodynamic variables such as intracranial pressure and blood gases. Mathematical models have been able to reproduce many known phenomena and to extract relevant parameters for...
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ژورنال
عنوان ژورنال: Physics in Medicine and Biology
سال: 2013
ISSN: 0031-9155,1361-6560
DOI: 10.1088/0031-9155/58/13/4381